|
Symbol Name ID |
Mapt
microtubule-associated protein tau MGI:97180 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Blepharospasm |
Eyelid apraxia |
Retrocollis |
Orthostatic hypotension due to autonomic dysfunction |
Dysphagia |
Photophobia |
Spasticity |
Frequent falls |
Astrocytosis |
Gliosis |
Substantia nigra gliosis |
Amyotrophic lateral sclerosis |
Cerebral cortical atrophy |
Neuronal loss in basal ganglia |
Cerebral atrophy |
Lewy bodies |
Neurofibrillary tangles |
Granulovacuolar degeneration |
Neuronal loss in central nervous system |
Senile plaques |
Bradykinesia |
Parkinsonism |
Parkinsonism with favorable response to dopaminergic medication |
Tremor |
Postural tremor |
Resting tremor |
Abnormal synaptic transmission |
Echolalia |
Monotonic speech |
Aphasia |
Delayed speech and language development |
Dysarthria |
Mutism |
Language impairment |
Depression |
Emotional blunting |
Emotional lability |
Irritability |
Low frustration tolerance |
Anxiety |
Panic attack |
Schizophrenia |
Hallucinations |
Visual hallucination |
Perseverative thought |
Diminished motivation |
Apathy |
Abnormal sexual behavior |
Inappropriate laughter |
Reduced social reciprocity |
Personality changes |
Polyphagia |
Disinhibition |
Impulsivity |
Agitation |
Restless legs |
Motor stereotypy |
Hyperorality |
Cognitive impairment |
Memory impairment |
Mental deterioration |
Dementia |
Frontal lobe dementia |
Frontolimbic dementia |
Frontotemporal dementia |
Short attention span |
Micrographia |
Sleep abnormality |
Insomnia |
Hyperreflexia |
Primitive reflex |
Akinesia |
Dyskinesia |
Dystonia |
Axial dystonia |
Limb dystonia |
Frontal release signs |
Falls |
Gait imbalance |
Shuffling gait |
Short stepped shuffling gait |
Unsteady gait |
Postural instability |
Pseudobulbar signs |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with MAPT | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| frontotemporal dementia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| late onset Parkinson's disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pick's disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| progressive supranuclear palsy |
| Mouse Phenotypes | nervous system phenotype |
decreased susceptibility to pharmacologically induced seizures |
abnormal axon extension |
abnormal motor neuron innervation pattern |
abnormal axon morphology |
abnormal dendrite morphology |
abnormal dorsal root ganglion morphology |
reduced long-term potentiation |
|
| Availability | Mouse Genotype | ||||||||
| Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt | |||||||||
| Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs | * | ||||||||
| Mapttm1Aha/Mapttm1Aha | |||||||||
| Mapttm1Hnd/Mapttm1Hnd | |||||||||
| Mapttm1Noh/Mapttm1Noh | |||||||||
| Mapttm2(cre)Aha/Mapttm2(cre)Aha | * | ||||||||
| Mapttm1Hnd/Mapt+ | |||||||||
| Chattm2(cre)Lowl/Chat+ Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr (conditional) |
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| Mapttm2Arbr/Mapt+ Pvalbtm1(cre)Arbr/Pvalb+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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